In multivariable analyses (Table 4), means for both B cell RANKL and B cell OPG changes were significantly different between both groups (P = 0.01 and P = 0.03, respectively) after adjusting for the osteoporosis risk factors: age, sex, race, BMI, smoking, alcohol consumption and fracture history. The gene discussed is TNFRSF11B; the disease is osteoporosis.