As shown in Figure 2A, the spontaneously produced levels of the IFNγ (GM of 70.1 pg/ml vs. 34.8 pg/ml), TNFα (GM of 69.7 pg/ml vs. 35.6 pg/ml) and IL-1β (GM of 64.4 pg/ml vs. 44.5 pg/ml) were significantly higher in TB-PDM compared to TB-NDM individuals. This evidence concerns the gene IFNG and tuberculosis.