TP53 and neoplasm: Furthermore, nuclear p53/Rb is almost undetectable in HPV-infected tumor cells due to their continuous inactivation caused by E6/E7 presence;30 this loss of p53/Rb contributes to the anti-apoptotic properties of E6/E7.9, 31 In agreement with these previous studies, we found that the DHA-mediated downregulation of E6/E7 and apoptosis induction was associated with increased nuclear staining for p53/Rb.