WWTR1 and kidney disorder: Interestingly, the kidney-specific YAP and TAZ knockout in an early developmental stage of the kidney on the other hand leads to alterations with cyst generation.37 Also proteins that cause nephronophtisis, a cystic degenerative kidney disease, are able to influence Hippo signaling.38, 39 Altogether these data indicate connections between changes in Hippo pathway activity and different kidney diseases.