Numerous studies have demonstrated that can regulate mTOR signaling in many cell lines, for instance, Huang et al. [39] have reported that EGCG inhibited the mTOR pathway through AMPK activation in cancer cells, Chen et al. [40] found that EGCG inhibited the proliferation of cancer stem cells via down-regulation of mTOR pathway, Peairs A et al. [41] reported that EGCG attenuated inflammation in MRL/lpr mouse mesangial cells via the PI3K/Akt/mTOR pathway. The gene discussed is AKT1; the disease is cancer.