ENG and preeclampsia: Among these, preeclampsia is characterized by increased placental expression and maternal systemic concentrations of anti-angiogenic sFlt-1 and soluble endoglin, which sequester circulating angiogenic factors, leading to an anti-angiogenic state, generalized endothelial dysfunction, hypertension and proteinuria [63]–[65], [74]–[81], [83]–[93], [95]–[98], [100], [102]–[106], [109]–[117].