HMGCR and Sepsis: Various adjunctive therapies with demonstrated or theoretical efficacy in severe sepsis were administered to Patient 5 and a few of the other patients, including HMG-CoA reductase inhibitors (statins), N-acetylcysteine [27], [28], recombinant factor VIIa, [29], [30], [31] mechanical ventilation, plasmapheresis, and hemodialysis.