Similarly, in mice, antiviral effects were observed with TLR3 signaling against poliovirus, coxsackievirus B, and encephalomyocarditis virus [47]–[50], whereas host-detrimental effects were observed with TLR3-triggered unbalanced inflammatory response in the infection of rhinovirus type 1B, vaccinia virus, respiratory syncytial virus, and influenza A virus [51]–[54]. Here, TLR3 is linked to infection.