NRAS and melanoma: Previous melanoma whole genome [11], [19], [42] and whole exome [18], [43], [44] studies have uncovered a complex landscape of melanoma genomes including high mutation rate, a complex copy number landscape, predominance of UV-related C>T transitions, and frequent genetic alterations in well-known drivers of melanomagenesis such as BRAF, NRAS, TP53, CDKN2A, and PTEN, which was corroborated in our study.