Our in silico significance and proximity analysis of 28 paired cases (13 WGS and 15 targeted cases) identified known (e.g., BRAF, NRAS, CDKN2A, and GRIN2A) and novel (e.g., EPHA3, GRIN2B, and ASXL3) genes involved in melanoma (Table 1 and Figure 2). The gene discussed is GRIN2B; the disease is melanoma.