Indeed it has been shown that plasmacytoid dendritic cells (pDCs) can respond to self DNA via TLR9 signaling, when self DNA is targeted to the endocytic compartment due to its interaction with circulating auto-antibodies in systemic lupus erythematosus [20] or with the antimicrobial peptide LL37 (cathelicidin antimicrobial peptide from hCAP18) in psoriasis [21]. The gene discussed is CAMP; the disease is systemic lupus erythematosus.