Of the up-regulated proteins, eleven proteins, including Calretinin, HtrA, Nox4, Flt1, HSP90, Ptx3, Endoglin, TFPI2, Ebi3, PSM, and PDEF were both up-regulated in preterm and term preeclampsia group, indicating their common roles in these two forms of preeclampsia (Figure 1A, overlap between two circles).PAI-1, Factor XIII B, EGFR, CD55, ALPP, Vimentin, p22-phox, Stat1, and WT1 were differentially expressed in preterm preeclampsia (Figure 1A, left circle), but not in term preeclampsia. This evidence concerns the gene SPDEF and preeclampsia.