Of the down-regulated proteins, five proteins, including AnnexinXI, PlGF, Bcl-6, p-MAPK(Erk1/2) and Glypican3 were down-regulated in both preterm and term preeclampsia, indicating their common roles in these two forms of preeclampsia (Figure 1B, overlap between two circles).PDEF, CREB, NF-kB p65, ICAM-1, Cdc25B, 14-3-3β, PCNA, Bcl-xL, Notch4, IGFBP3, PAPP-A, Met-RS, p-PKCα/βII were differentially expressed in preterm preeclampsia (Figure 1B, left circle), but not in term preeclampsia. The gene discussed is PAPPA; the disease is preeclampsia.