Although we can not rule out that other factors could be also affecting HMVEC-L susceptibility, the possibility that Gal-1 might restricts viral entry is corroborated by our findings, showing that addition of exogenous Gal-1 inhibits virus adsorption to ECV-304 cells and its internalization during in vitro infection (Figure 4B). The gene discussed is LGALS1; the disease is infection.