Increased sCD163 serum concentrations have been reported in patients who suffer from various infectious and inflammatory diseases, such as sepsis, tuberculosis, diabetes, acquired immune deficiency syndrome, liver disease, dengue fever, rheumatoid arthritis and hemophagocytosis [22], [23]; however, the physiological role of sCD163 was unknown, until now. Here, CD163 is linked to Hemophagocytosis.