The plasma sCD163 level in the HFRS patients decreased during the convalescent phase (febrile/hypotensive vs. diuretic or convalescent, P <0.0001; oliguric vs. convalescent, P = 0.001); however, it was still higher than the levels observed in the normal controls (diuretic vs. NC, P = 0.004) (Figure 1A). Here, CD163 is linked to hemorrhagic fever with renal syndrome.