Firstly, female breast cancer diagnosed at a young age tends to have worse prognosis, namely fast-growing, high grade and hormone receptor-negative tumors (Anders et al. 2008; Fei et al. 2013; Partridge et al. 2010), and as a consequence a higher cause-specific mortality (Aebi et al. 2000; Albain et al. 1994; Anders et al. 2008; de la Rochefordiere et al. 1993; El Saghir et al. 2006; Holli and Isola 1997; Kollias et al. 1997). The gene discussed is NR4A1; the disease is breast cancer.