A survey of LEF1 expression in primary myelogenous leukaemias determined that LEF1 mRNA and other Wnt target genes (c-MYC) are increased in the final blast phase (BP) stages of chronic myeloid leukaemia (CML) compared with those from earlier, slower growing chronic phases (CPs) [7]. This evidence concerns the gene LEF1 and myeloid leukemia.