However, even though hippuristanol triggered an increase in the level of phospho-S6K (active mTOR), there was no compensatory increase in LEF-1 or RUNX1 protein synthesis or cap-dependent translation (GAPDH) in CML, Jurkat and AML cell lines (figures 3c and 4b,c; electronic supplementary material, figure S5). This evidence concerns the gene LEF1 and chronic myelogenous leukemia, BCR-ABL1 positive.