It has been shown that LEF1 transcripts are upregulated in advanced CML [7]; therefore, we determined whether LEF-1 protein is detectable in primary CML isolates and whether expression is due to the actions of the major oncogene Bcr-Abl or its downstream target, mTOR kinase, a central regulator of cap-dependent translation. Here, LEF1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.