Berndt et al. examined 5 SNPs in XPC among 250 colorectal cancer patients and 2,228 controls, authors suggested increased risk of colorectal cancer among patients having at least one 492His allele of the XPC Arg492His (rs2227999) and no association of the remaining SNPs (including rs2228001 and rs2228000) with colorectal cancer [13]. The gene discussed is XPC; the disease is colorectal cancer.