A meta-analysis that included 15 studies (Lys751Gln) containing 3,042 CRC cases and 4,672 controls and seven studies (Asp312Asn) containing 1,581 cases and 2,846 controls, suggested that both polymorphisms in XPD are not significantly associated with CRC risk [19]. The gene discussed is ERCC2; the disease is colorectal carcinoma.