Analyzing the results of the LRRK2 p.G2019S mutation in a large cohort of Russian patients with sporadic and familial PD, we found that all patients carrying the LRRK2 p.G2019S exhibited typical levodopa-responsive parkinsonism, with asymmetric onset of symptoms and variable combination of bradykinesia, rigidity and rest tremor[31]. This evidence concerns the gene LRRK2 and Parkinson disease.