LRRK2 and Parkinson disease: In addition to the common p.G2019S carriers, the present study highlights that the distribution in age at onset and clinical features in LRRK2 p.R1441C patients are similar to idiopathic and LRRK2 p.G2019S parkinsonism, indicating that the effect of mutations in different domains of the LRRK2 protein lead to similar phenotypes[34].