TDP-43 mislocalization is associated with CUG repeat expansion diseases (Schwab et al, 2008; Hart & Gitler, 2012), as well as with the recently identified C90orf72 ALS-FTD mutation, which consists of an expanded GGGGCC repeat (DeJesus-Hernandez et al, 2011). Here, TARDBP is linked to amyotrophic lateral sclerosis.