Immunization with AGE-LDL using Alum as adjuvant resulted in a significant reduction in atherosclerotic lesion burden compared to mice immunized with PBS control (76% in LDLR null diabetes mellitus(DM) mice, p < 0.01; and 43% in apoE null DM mice, p < 0.01) or Alum alone (50% in LDLR null DM mice, p < 0.05; and 20% in apoE null DM mice, p < 0.05) (Figure 1). This evidence concerns the gene APOE and diabetes mellitus.