The present study showed that combined treatment with human AGE-LDL and Alum adjuvant induces effective immunity against atherosclerotic progression in diabetic animal models with atherosclerosis, possibly mediated by activation of protective autoantibodies production and Tregs, as indicated by increased AGE-LDL specific IgM and IgG titers and Foxp3 and IL-10 expression, respectively. The gene discussed is FOXP3; the disease is atherosclerosis.