Along with G-6Pase, which is mutated in Glycogen Storage Disease Type 1 (GSD1), G-6Pase 3 belongs to the glucose-6-phosphatase (Glc-6-Pase) family, a group of transmembrane, endoplasmic reticulum (ER)- associated proteins [3]. The gene discussed is G6PC1; the disease is glycogen storage disease I.