Although we did not detect evidence of an increased genomic instability in LVI-positive breast tumors, some specific rearrangements could be detected at a slightly higher frequency in this group compared to the LVI-negative group, such as gains at 5p, 17q12 (ERBB2), and 19, and losses affecting 8p, 11q, 18q, and 21 (Fig. 1c). Here, ERBB2 is linked to breast neoplasm.