HMGA2 and cancer: The 8q22 gain is reportedly related to poor prognosis and chemoresistance possibly due to the activation of MTDH [33], although the 8q22 segment here detected did not harbor this gene and included the cancer gene COX6C, which is involved in oxidative metabolism, upregulated in prostate tumors, and fusioned to HMGIC gene in uterine leiomyomas [34, 35].