Overexpression of HSD17B12 was recently associated with COX2 (1q31) overexpression in breast carcinomas [47], and in our cohort, HSD17B12 gains were detected in association with COX2 gains, which may indicate a new 1q31/11p11 co-amplification pattern in ER-negative high-grade breast tumors. Here, HSD17B12 is linked to breast carcinoma.