A panel of 16 genes exhibited copy number changes at higher frequencies in high-grade tumors compared to low-grade samples (losses affecting PPP2R2A, CDKN2A, MTAP, RERGL, RB1, PTEN, INPP4B and gains of CCNE1, ERBB2, EGFR, FGFR1, GATA3, MYC, HSD17B12, ZNF703, and ZNF217; Fig. 4a); conversely, copy number losses of TP53, CDH1, and NCOR1 were detected preferentially in low-grade breast tumors. Here, HSD17B12 is linked to breast neoplasm.