IL6 and hand, foot and mouth disease: The serum levels of IL-6 of the cases were significantly higher than in the controls during HFMD from days 2 to 5 as follows: 53.22 (47.42∼63.12) vs. 21.40 (16.99∼28.16), 72.49 (56.61∼75.61) vs. 27.97 (26.42∼30.43), 65.20 (44.91∼79.52) vs. 25.71 (22.31∼29.42), and 35.70 (31.46∼43.29) vs. 24.20 (22.31∼26.48), respectively (P = 0.019 for the 2nd day and P<0.001 for the other days).