NF1 and Cognitive impairment: Despite a phase I study suggesting that lovastatin (20–40 mg/day, 3 months) treatment in 10–17 year-old children with NF-1 may have potential benefits on cognitive parameters [110], a recent randomised controlled trial found no effect of simvastatin (10–40 mg/day, 12 months) on cognitive deficits or behavioural outcomes in children aged 8–16 with NF-1 [111].