Several statins (lovastatin, mevastatin, fluvastatin and simvastatin) have also been found to increase caspase-3 mediated apoptosis and decrease extracellular-signal-regulated kinases (ERK) 1/2 and Akt, also known as protein kinase B, in C6 glioma cells through GGPP-dependent mechanisms [156,157]. This evidence concerns the gene AKT1 and glioma.