In this context, a recent Genome Wide Association Study (GWAS) has provided evidence that the genetic variant rs897 in 3′UTR of VPAC-1, mapping 31 bases from rs896, is strongly associated with Alzheimer's disease (AD), especially with the late-onset form (LOAD) that has a complex multifactorial background [28]. The gene discussed is VIPR1; the disease is early-onset autosomal dominant Alzheimer disease.