In both primary hippocampal/cortical cultures and in the SKOV-3 tumor cell line, sigma-2/PGRMC1 agonist siramesine activated caspase-3/7 (Fig. 8A, B) while CT0109, CT0093 and the sigma-2 antagonist RHM-1 did not. The gene discussed is AP2S1; the disease is neoplasm.