GASC/Gasc are therefore different from the glioma-initiating-stem cells (defined as GSC for HG and Gsc for LG) that grow in adhesion on laminin and are described as tumor-derived cells able, once transplanted into immunocompromised mice, to give rise to a tumor that is the phenocopy of the patient’s one [10]–[12]. The gene discussed is GDF15; the disease is neoplasm.