FASLG and cryopyrin-associated periodic syndrome: CAPS, a fatal variant of APS, with a prevalence of 1% of APS population, was first described in 1992 and defined as thrombosis of at least three different organ systems over a very short period of time with histopathologic evidence of multiple small vessel occlusions and high titers of antiphospholipid antibodies (aPL) [1–5].