In this respect dietary interventions through hitting multiple targets for AD: amyloid-Aβ1-42 aggregation, neuroinflammation, synaptic plasticity, and tau (microtubule-associated protein) phosphorylation, can offer unique advantages to attenuate the self-propagating course of AD and to prevent the transition from MCI to early AD [7]. Here, MAPT is linked to Alzheimer disease.