Loss of GSTP1 function may contribute to the early stages of PCa development, with GSTP1 methylation evident in 5–10% of proliferative inflammatory atrophy (PIA) precursor lesions, and 70% of high-grade prostatic intraepithelial neoplasia (PIN) lesions, respectively [6]. The gene discussed is GSTP1; the disease is proliferative inflammatory atrophy.