At present, eight MMR genes are known (hMLH1, hMLH3, hMSH2, hMSH3, hMSH6, hPMS1, hPMS2, and hEPCAM); however, the vast majority of Lynch syndrome cases (90–95%) result from germline hMLH1 and hMSH2 mutations [15]. This evidence concerns the gene MRC1 and Lynch syndrome.