The variant showing strongest significance was rs63750847, predicted to cause an amino acid substitution (A637T, ESP MAF 0.01% in EA, not recorded in AA) at the second position in the Aβ peptide region of APP. The variant was reported to be significantly more common in elderly healthy controls than AD subjects (OR 5.29, p = 4.78 × 10-7), indicative of a protective effect against the development of AD. The gene discussed is APP; the disease is Alzheimer disease.