Additional replication for the association between R47H and AD risk has been provided in subjects of French origin (see Table 1; Pottier et al., 2013), as well as suggestive association with R47H and R62H in the Belgian population, where a gene based association test attained statistical significance [relative risk = 3.01 (95% CI 1.29 - 11.44), p = 0.009; Cuyvers et al., 2014], strengthening the evidence for TREM2 ’s association with AD in subjects of European origin. Here, TREM2 is linked to Alzheimer disease.