Of the 44 SNPs genotyped in the first follow up cohort (including ∼400 AA cases and controls), two rare SNPs within the gene AKAP9 showed nominally significant associations with AD in single SNP association tests (rs144662445, with p = 0.014 and OR 8.4 and rs149979685, p = 0.037. This evidence concerns the gene AKAP9 and Alzheimer disease.