Examining both the cytokine profile and tumor protection capacity within a panel of type I NKT agonists, there was a strong correlation between the Th1 profile (in terms of IFN-γ:IL-4 ratio or IFN-γ production) and magnitude of protection in the mice from tumor growth in CT26 lung metastasis model (67). The gene discussed is IFNG; the disease is neoplasm.