CD28 and neuroblastoma: Autologous patient T cells will be transduced with a retroviral vector encoding a third-generation GD2-specific CD28.OX40.ζ CAR (Pule et al., 2005), which was developed by the Brenner group in a first-generation CAR format for phase 1 clinical evaluation in neuroblastoma patients (Pule et al., 2008; Louis et al., 2011), and then modified further to encode iCasp9 (Gargett et al., 2014).