DISC1 and major depressive disorder: Supporting the involvement of Miro alteration in the pathogenesis of other neurological diseases, DISC1 (Disrupted in Schizophrenia 1), a candidate risk factor for schizophrenia, bipolar disorder, and depression, has been shown to interact with TRAK1 and Miro1 to promote axonal mitochondrial transport, and a putative disease-associated variant 37W impairs DISC1 function in this process (Ogawa et al., 2014).