Biochemically, it was found that PINK1 and another PD associated gene product, Parkin, acted together to promote the degradation of Miro in vivo in Drosophila tissues, or in cultured mammalian cells treated with the mitochondrial toxin CCCP (Wang et al., 2011; Liu et al., 2012). The gene discussed is PRKN; the disease is Parkinson disease.