Acute hyperglycemia, induced by glucose infusion for 10 min prior to the induction of 10 min of forebrain ischemia, significantly increased the ICAM-1 protein levels in the brain homogenate and plasma together with elevations in superoxide radicals, malondialdehyde, high-mobility group box 1, and key markers of lipid peroxidation [30]. Here, HMGB1 is linked to Hyperglycemia.