Preliminary data 41 from studies by our team in multiple intestinal neoplasia (Min) mice, that exhibit polyposis because of a genetic defect in the Apc gene, suggest that administration of EGF does not increase the number of polyps or degree of dysplasia, but does cause a 40% increase in polyp size in the proximal intestine specifically (P < 0.02). The gene discussed is APC; the disease is polyp.