In our study, cerebral ischemia promoted neurogenesis in the SGZ, and edaravone administration increased BrdU-labeled cells and BrdU + /NeuN + cells in the SGZ after 10 min of global cerebral ischemia, indicating that edaravone enhances hippocampal stem/progenitor cell neurogenesis. This evidence concerns the gene RBFOX3 and Cerebral ischemia.