PIK3CA and cancer: Consistent with previous reports, autophagy inhibition could potentiate the apoptosis induced by ABT-737 or aspirin when cancer cells were resisted to ABT-737 or aspirin by inducing protective autophagy as a self-defence mechanism, while autophagy inhibition markedly decreased apoptosis induction by the combination of aspirin plus ABT-737 in PIK3CA wild-type cell lines A549 and H1299 cells 25,26.