We used the MC38-CEA murine colon carcinoma cell line which expresses both VEGFR2 and MET (Figure 1A, inset), in addition to the human carcinoembryonic antigen (CEA), to examine the in vitro immunomodulatory effects and in vivo antitumor effects of cabozantinib. Here, CEACAM5 is linked to colon carcinoma.