We suggested that, chronic exposure to pelvic micro-environments, which is characterized by overproduced inflammatory factors 2,4 (inducible nitric oxide synthase, iNOS; Cyclooxygenase-2, COX-2), oxidative stressor (lipid peroxide, LPO) and estradiol, might induce oviduct TCs damage and is then involved in structural and functional oviduct abnormalities, such as the observed dysmotility of oviduct 6, until finally contributing a significant role in EMs-associated tubal factor sub- or infertility. This evidence concerns the gene NOS2 and Infertility.