TYK2 and Immunodeficiency: We examined known genes associated with immune deficiency, including the HIES genes STAT3, TYK2, STK3 and DOCK8, and observed no damaging mutations in STAT3 or STK3, heterozygosity for a possibly damaging missense variant in TYK2 (rs147991080, R448W, MAF <0.01 (http://browser.1000genomes.org/); Table S2), and large deletions on both copies of chromosome 9p in the region that includes DOCK8.