The reasons lied in the increased risk of cerebrovascular and cardiovascular complications in patients after long-term take of COX2 inhibitors are that COX2 inhibitors selectively inhibit PGI2 in the blood vessel wall without the concomitant inhibition of TXA2, and could promote hypertension and thrombosis, and increase cardiovascular risks [43]. The gene discussed is PTGS2; the disease is Hypertension.