In view of the significance of Ang II and its receptor proteins in the pathophysiology of ischemic stroke, the present study aimed to explore the potential mechanism mediating the beneficial effects of EA from the respect of Ang II and its receptors-mediated signal transduction pathways, and the time-course effects of EA on experimentally induced cerebral ischemic rats was systematically investigated within the first 24 h. Here, AGT is linked to ischemic stroke.