While additional studies involving more C-HIV Envs isolated over longer periods of time are required to confirm these findings, our data support those from a study by Buzon et al. [6], which showed that the susceptibility of TSCM to infection by R5 subtype B HIV-1 is maintained during disease progression, and those from a study by Chomont et al. [1], which showed that HIV-1 can persist in TCM and TTM of subjects who exhibit reconstitution of CD4+ T-cells during suppressive antiretroviral therapy. Here, CD4 is linked to infection.