Some classical lncRNAs have been found to be dysregulated in a variety of cancers and have been shown to possess clinical potential as diagnostic biomarkers and therapeutic targets due to their aberrant expression is significantly associated with carcinogenesis, metastasis or prognosis, such as H19, HOTAIR, MALAT1, MEG3, and XIST [16,17]. The gene discussed is HOTAIR; the disease is cancer.