Since ALCL cell lines were the most sensitive to the pan-PIMi ETP-39010, and PIM2 expression was preliminarily associated with poor prognosis in our limited ALCL series, we decided to explore the therapeutic relevance of the PIM pathway in ALCL, especially in the ALK+ ALCL subtype, because ALK translocation is known to activate STAT3 [5], [6], and STAT3 triggers PIM2 expression [13], [14]. This evidence concerns the gene PIM2 and anaplastic large cell lymphoma.