Some studies have recently described the efficacy of ALK inhibition in ALCL, both in murine models [40] and in preliminary clinical studies: in one trial 2 ALK+ ALCL patients reported complete remission of the disease within 1 month of treatment with Crizotinib, the response being sustained 5–6 months later [8]. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.