PIM family members, especially PIM2, were found to be overexpressed in PTCL, as in many other tumor entities of hematological or epithelial origin, such as chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, acute myeloid leukemia, and prostate, pancreatic, gastric, colon and hepatocellular carcinomas [13], [15]. The gene discussed is PIM2; the disease is B-cell chronic lymphocytic leukemia.