ALK and neoplasm: These findings correlate with the fact that the ALK rearrangement appears to be a homogenous event in the tumor population [26], [29], Enumeration of <50 nuclei is not advisable because this number is based on the minimal number that is statistically needed to be able to reliably define a sample without FISH break signals (<15% of nuclei) as a case without ALK rearrangement.