CALR and neoplasm: An additional important prerequisite for the immuno-elimination of tumor cells using the calreticulin “eat-me” signal is autophagy: the inhibition of autophagy significantly increases the amounts of calreticulin on the surface of stressed tumor cells, suggesting that autophagy-competent cancer tissue may be less susceptible to calreticulin-mediated immunorecognition of tumor cells (82, 83).