When BSI was added to a prognostic base model includingage, prostate-specific antigen, clinical tumour stage and Gleason score, theconcordance index increased from 0.73 to 0.77 (p =0.0005) at baseline andfrom 0.77 to 0.82 (p <0.0001) during ADT. The gene discussed is KLK3; the disease is neoplasm.