Once the patient was transferred to our facility, and the work-up concluded that the patient had plasma cell myeloma, with an underlying early BCL/ABL positive CML and an underlying Jak2 V617F positive myeloproliferative disorder, the patient continued a weekly treatment of bortezomib and anti-CML therapy was initiated. This evidence concerns the gene JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive.